Mitosis Skill Tree: How to Open It and What Token Unlocks Give You
The Mitosis skill tree opens after your first rebirth. Rebirth to earn Tokens, spend them on skill tree nodes, and keep the permanent boosts through every rebirth.
The Mitosis skill tree is locked until you rebirth. Your first rebirth is what opens the tree, and it's also what earns you Tokens — the currency you spend on the tree's nodes. Every node you unlock adds a permanent boost, and those boosts stick around after every rebirth that follows.

How to open the skill tree
- Play the normal loop. Split and sell cells for Cash, and buy upgrades to grow faster. If you're just starting out, the Mitosis beginner guide covers the basics.
- Rebirth. Rebirthing resets your progress, but it earns Tokens and opens up the skill tree — it's the gate for the whole feature.
- Spend Tokens on nodes. Once you've rebirthed, the tree is available to you, and Tokens are what unlock its nodes.
What the nodes give you
Each node you unlock with Tokens adds a permanent boost that survives every later rebirth. That's the whole point of the tree: a rebirth resets your run, but the boosts you've already unlocked stay yours, so each rebirth leaves you permanently stronger than the last. The tree is massive, too, so there's plenty to keep working through as you rebirth again and again.
Where Tokens come from
Rebirths earn Tokens, which is what links rebirthing to filling out the tree: the same action that opens it also funds it. For more on the currency itself, see Mitosis Tokens. And while you're building toward your next rebirth, Mitosis codes can hand you free rewards along the way.
Related Guides
Rebirth: What You Get and What Stays
Learn what a rebirth resets, which boosts stay permanent, and how the Token payout sets up the skill tree.
Tokens: Where They Come From, What They Buy
Find every way to earn Tokens and the skill tree nodes and cards they unlock.
Upgrades: What Cash Buys
See what Ball Value, Split Speed and Capacity each do, and how to check any upgrade panel before spending.
